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New Bat Coronavirus Raises Human Infection Concerns

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  • New bat coronavirus HKU5-CoV-2 discovered in Chinese bats
  • Virus uses ACE2 receptor to infect humans, similar to SARS-CoV-2
  • Study conducted by Wuhan Institute of Virology, published in Cell journal
  • HKU5-CoV-2 poses a zoonotic risk to humans
  • Further investigation required to assess human disease potential
360 summary
  • Monoclonal antibodies and antiviral drugs could be effective in treating a bat virus like HKU5-CoV-2 if it infects a human.
  • Antiviral drugs are designed to halt the spread of the virus in the body, potentially alleviating symptoms and shortening the duration of illness.
  • Monoclonal antibodies, specifically tailored to target the spike protein of viruses like SARS-CoV-2, could be crucial in preventing infection in individuals with weakened immune systems.
ForbesForbes
  • The study highlights that HKU5-CoV-2 has a better adaptation to human ACE2 compared to lineage 1 HKU5-CoV.
  • Authentic HKU5-CoV-2 was found to infect human ACE2-expressing cell lines and human respiratory and enteric organoids, indicating its ability to interact with human cells.
  • This research underscores the zoonotic risk posed by HKU5-CoV-2, suggesting a potential for transmission from bats to humans through direct or intermediate hosts.
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